pMetabolic conditioning

Classical conditioning of Metabolic responses (animals)




(page 11 of handout)

Woods (1976)

UCS was presence of insulin in an injection.

CS was getting an injection + being placed in a holding cage smelling of mentholatum (for 20 mins, after which blood sample was taken from the tail)  











(page 11 of handout)


The reference for this was left off the paper handout. It is

Russell, M., Dark, K. A., Cummins, R. W., Ellman, G., Calloway, E. and Peeke, H. V. S. (1984). Learned histamine release. Science, 225, 733—4.

2. Russell et al (1984)

Guinea pigs tested for plasma histamine release – 10 minutes after a trial animal was anaesthetised and blood withdrawn for testing

US was bovine serum albumen

CS+ and CS- were sulphur and fish smells — only one (CS+) paired with the US

Trials given one week apart  






3. Siegel (1975,1976)

(page 11 of handout)

Rats were made tolerant to morphine in one of two environments (different rooms with different enclosures) and then assessed for morphine tolerance in both. They only showed tolerance in the same room they had previous experience of. Theory is that the body antagonises the drug ( so it's less effective) and that it is antagonism to the drug that is conditioned to environmental stimuli

Extinction is produced if the cues given without the drug i.e. saline injections in room bring back the original effects of the same dose of morphine, but when saline is first given the rats are jump and hypersensitive, suggesting that an anti-sedation effect is still present (Siegel, 1975).

See Gleitman (1995, page 114; 1999, p. 126) 

  cf stimulus-substitution theory

What is associated may vary — different components of the UCR may be moved to the CR, and what is produced as the CR may also depend upon the precise characteristics of the signal and “affective responses”.